Dna Damage Concepts

[LeeAndro]

Last updated 5/2022MP4 | Video: h264, 1280x720 | Audio: AAC, 44.1 KHzLanguage: English | Size: 876.00 MB | Duration: 2h 3m

understand DNA damage related all concepts

What you'll learn
DNA damage Introduction
Types of DNA damage
Endogenous damage
Exogenous damage
Point Mutation
Frameshift Mutation
Consequences of Silent and Missense Mutations
Nonsense mutation
Consequence of Frame shift mutation
Disadvantages
Preventive measures
Requirements
Any life science student can learn
Description
DNA damageDNA damage can occur due to various factors such as ionizing radiations, UV light, certain chals and also certain metabolites, which can induce oxidative damage to DNA.​

Example reactive oxygen species.Besides the possible errors in replication, the DNA is constantly subjected to attack by both physical and chal agents.These include radiations, free radicals ,chals etc.,Which also result in mutation.It is fortunate that a great majority of the mutations probably occur in the DNA that does not encode proteins, and consequently will not have any serious impact of the organism.This is not ,however , all the true , since mutations do occur in the coding regions of DNA also. There are situations in which the change in single base pair in the human genome can cause a serious disease.example sickle-cell anemia Types of DNA damages:The damage done to DNA by physical ,chal and environmental agents may be broadly classified in 4 categories.1.single base alterations2.two base alterations.3.chain breaks.4.cross- linkages.Since the sources of DNA damage can be roughly divided into two main groups, endogenous damage and exogenous damage. The endogenous damages are the damage caused by reactive oxygen species or some agents else produced from normal metabolic by products, while exogenous damages are caused by external agents, like some radiations, include UV, x-rays; plant toxins; chals; viruses.Mutations refers to a change in the DNA structure of a gene.The substances which can induce mutations are collectively known as mutagensA mutation is a change in the DNA sequence of an organism. Mutations can result from errors in DNA replication during cell division, exposure to mutagens or a viral infection.For further learning and more you can find in explanation.

Overview

Section 1: Introduction

Lecture 1 DNA damage Introduction

Lecture 2 Types of DNA damage

Lecture 3 Endogenous damage

Lecture 4 Exogenous damage

Lecture 5 Point Mutation

Lecture 6 Frameshift Mutation

Lecture 7 Consequences of Silent and Missense Mutations

Lecture 8 Nonsense mutation

Lecture 9 Consequence of Frame shift mutation

Lecture 10 Disadvantages

Lecture 11 Preventive measures

All life science students

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