Handbook of Preformulation: Chemical, Biological, and Botanical Drugs, Second Edition by Sarfaraz K. Niazi
2019 | ISBN: 1138297550 | English | 574 pages | PDF | 10 MB
Preformulation studies are the physical, chemical, and biological studies needed to characterize a drug substance for enabling the proper design of a drug product, whereas the effectiveness of a drug product is determined during the formulation studies phase. Though the two disciplines overlap in practice, each is a significantly distinct phase of new drug development.
Entirely focused on preformulation principles, this fully revised and updated Handbook of Preformulation: Chemical, Biological, and Botanical Drugs, Second Edition provides detailed descriptions of preformulation methodologies, gives a state-of-the-art description of each technique, and lists the currently available tools useful in providing a comprehensive characterization of a new drug entity.
Features:
Addresses the preformulation studies of three different types of new active entities - chemical, biological, and botanical, which is the latest established class of active ingredient classified by the FDA
Illustrates the activities comprised in preformulation studies and establishes a method of tasking for drug development projects
Includes extensive flow charts for characterization decision making
Gives extensive theoretical treatment of principles important for testing dissolution, solubility, stability, and solid state characterization
Includes over 50% new material
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